It appears that 4-hydroxyisoleucine is far more potent than any other insulin mimetic or insulin potentiator currently in use as a dietary supplement. For example, it has been shown to potentiate insulin secretion 25 times more effectively than leucine, 15 times more effectively than isoleucine, and begins to workout 1/10th the dosage of these two amino acids. It has also been shown to beat out arginine in terms of insulin potentiation. Moreover, 4-hydroxyisoleucine is unique from these other compounds in that it has a nutrient partioning effect, which means it may help to shuttle nutrients to muscle cells preferentially over fat cells.
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